Posts Tagged ‘weight loss’

Mental health often, but not always, improves after metabolic and bariatric surgery. But new research tells us that this is not really a direct consequence of weight reduction. Instead, it seems that better mental health very likely comes from the reduction in experiences of weight stigma. In fact, Larissa McGarrity and colleagues found that the […]

This should not be so hard. But apparently it is very hard for people to accept, in their hearts, that the disease of obesity is actually chronic. Yes, people will repeat the words that experts and thought leaders have fed them. “It is undeniable that obesity is a complex, chronic disease.” So says the International […]

At ECO2025 today, a new analysis from the landmark SELECT trial reveals that heart health benefits with semaglutide can start early for people with obesity and pre-existing heart disease. Within just three months, semaglutide reduced the risk of major cardiovascular events (MACE) by 38% compared to placebo. By six months, this risk dropped by 41%. […]

This is quite a day for the folks who have invested energy and others who have invested a great deal of money into developing tirzepatide for obesity. They took the risk of doing a head-to-head study of this drug against semaglutide and it clearly paid off. In the SURMOUNT-5 study, tirzepatide came out ahead on […]

It’s too dangerous, say some. In fact, quite sincerely, smart physicians have told us that the widespread use of compounded semaglutide represents a public health crisis. Others have told us that, yes, there are risks. But because of drug pricing and health insurance practices, it is the only option for many patients and they have […]

Let’s talk selfies. For me, they were my reality check. Full-body shots? Forget it. Every milestone photo with my family got run through every beautification filter the App Store could throw at me, but nothing could match the image I wanted to see staring back. That’s when I knew – it was time for a […]

Drug development for obesity may well be in a golden age. In large part, this is because the scientific understanding of obesity has grown exponentially in the past two decades. Unfortunately, little or none of that is reflected in new draft guidance from FDA, issued yesterday for public comment, on developing the next generation of […]

It used to be that this was the time of year when popular culture turned its attention to weight loss season. The release of U.S. News rankings of “Best Diets” commanded media attention. Weight loss tips were everywhere. But no more is this true. No, idle talk about weight loss has not disappeared. But it […]

Bragging rights. Yesterday, Lilly claimed them for its obesity medicine, the Zepbound brand of tirzepatide. The company announced topline results from a head-to-head trial of tirzepatide vs semaglutide for weight loss in persons with obesity or overweight and at least one obesity-related complication. It should be no surprise that tirzepatide won this narrowly-defined contest. In […]

As we travel to San Antonio for ObesityWeek 2024 (OW2024) one of the principal threads we want to explore is the expanding scope of GLP-1 therapy benefits. The narrative is a moving target. We won’t have the abstracts in hand for another day. But news this week makes it clear that we have barely gotten […]