Posts Tagged ‘semaglutide’

The news in obesity research these days is so full of headlines about a multitude of new medicines in development that it is easy to lose count. All too often, these are early stage or even pre-clinical notions of a potential treatment. So yesterday, it was good news indeed to hear that a once-daily oral […]

The opening of the American College of Cardiology meeting in Chicago yielded good news on semaglutide from two major studies. A morning presentation  and simultaneous publication in Lancet showed semaglutide reduces symptoms of peripheral artery disease in persons with diabetes. Then, in the afternoon, researchers presented data and published it in the New England Journal […]

There’s no denying it. More people are getting access to care for obesity than ever before. In part this is because health professionals have a range of tools for providing that care. GLP-1 agonists like semaglutide and tirzepatide are a big part of that.But those drugs carry a price tag that is blowing up pharmacy […]

It’s unmistakable. A quick look at the upcoming meeting of the American College of Cardiology in Chicago tells us that obesity care has a growing role in cardiology. The meeting starts March 29 and a total of 27 educational sessions will focus on obesity. Three late breaking publications – two for semaglutide and one for […]

Intriguing observations on the effect of retatrutide on cancer progression in mice appeared Friday in NPJ Metabolic Health and Disease. Retatrutide is the first triple agonist to progress in clinical development for obesity. Lilly said recently that they expect to release phase three clinical trial data for it later this year – earlier than previously […]

A new analysis in JAMA Health Forum yesterday shines a harsh light on pricing for new obesity medicines. In a rigorous econometric analysis, researchers found that new and highly effective medicines for obesity – Wegovy (semaglutide) and Zepbound (tirzepatide) – are both overpriced. They also found that the price and value of Wegovy was out […]

Drug development is tricky. If you want evidence for just how tricky it is, a quick look at the experience with CagriSema will give you a pretty good idea. Yesterday, Novo Nordisk announced topline results of this drug from their REDEFINE 2 clinical trial. Their press release talked about “superior results” for people with overweight […]

It’s official. FDA yesterday declared that the semaglutide shortage is over and now we wonder how quickly and completely the compounding of obesity medicines will vanish. From the very first days of launching semaglutide for obesity in 2021, demand has outstripped supply. The FDA officially declared the shortage in March 2022. So it feels vaguely […]

Early on after semaglutide captured public attention, people started noticing that the drug was not only helping people reduce excessive weight, it seemed to reduce the desire for drinking alcohol. But until now, all we’ve had to support this idea were anecdotes and retrospective observational studies. Yesterday, JAMA Psychiatry published an RCT offering stronger evidence […]

The revolution in obesity care brought on by semaglutide and tirzepatide is beginning to look a little shaky, says Tina Reed on Axios. The U.S. healthcare system is skimming profits from them, thus sowing disparities, and quite possibly dimming the prospects for broad gains in health. Peter Antall is Chief Medical Officer at the digital […]