Posts Tagged ‘obesity complications’

Sleep apnea is a complication of obesity and at the same time, obesity can be a complication of sleep apnea. This two-way relationship sets up a problem that is serious and can be hard to resolve. But it deserves close attention because it can lead to an early death. So, given the tangled relationship between […]

For an early stage of hepatic steatosis called MASLD, JAMA has just published results from an intriguing study. It is a small RCT showing that low-dose aspirin can significantly reduce fat in the liver of persons with MASLD and without cirrhosis. MASLD is a new acronym for metabolic dysfunction-associated steatotic liver disease. You might know […]

Firsts are worth celebrating. In this case, the cause for celebration is especially great. MASH or metabolic steatohepatitis is a disease that is growing dramatically more common and more harmful to the health of the population. Late this week, FDA approved resmetirom to be the first ever treatment for MASH with fibrosis. Note that the […]

Yet another GLP-1 agonist in development for obesity – survodutide – showed promising results yesterday from a phase 2 clinical trial in MASH. In case you missed the notice, MASH is the new acronym for what we used to label as NASH. We also note that MASLD has replaced NAFLD in the nomenclature alphabet soup […]

The potential for benefits to brain function with effective obesity treatment is becoming difficult to miss. In particular, a new observational study of brain function in a cohort of patients receiving metabolic surgery for treatment of obesity is drawing much attention right now in JAMA Network Open. It suggests the possibility of a lasting benefit […]

Let’s be clear from the start. Hype about “weight loss” drugs is exquisitely unhelpful. This is because weight loss is only an acute effect of new medicines that act on GLP-1 receptors and related pathways that influence obesity. The real need for these medicines is to control a whole range of chronic health problems that […]

Cancer is rising in young persons and it appears that obesity is playing a role. Of course, this is not to say that obesity tells the whole story. Cancer prevalence patterns present a complex puzzle – just as obesity prevalence does. A Continuing Shift Toward Younger Persons Yesterday in CA: A Cancer Journal for Clinicians, […]

Scientists who study semaglutide in obesity are producing a steady stream of impressive results. Yesterday in the New England Journal of Medicine, a randomized controlled trial in persons with obesity and heart failure with preserved ejection fraction demonstrated superior weight reduction, improvement in heart failure, better physical functioning, and a halving of serious adverse events. […]

JAMA Pediatrics has a pair of new papers today on the cost of childhood obesity. One of them adds up the medical expenses incurred by youth aged 2 to 19. The other editorializes about determining the value of interventions to manage weight. Both of them focus on pricing childhood obesity in the present while discounting […]

At the ASMBS Annual Meeting this week, a new study of major bad outcomes in people with both obesity and sleep apnea reminds us why metabolic surgery remains an important option for comprehensive obesity care. The risk of death, heart attacks, strokes, and other major bad cardiovascular outcomes is 37 percent lower if a person […]