Posts Tagged ‘obesity complications’

When people take a GLP-1 like semaglutide, osteoarthritis often improves. It makes sense. Excess body weight puts a strain on joints, especially the knee. And randomized controlled studies document the clinical benefits. New research confirms what clinical scientists have long suspected. Treating obesity can do more than just relieve the strain of excess weight on […]

Observational studies have suggested for some time that obesity might raise the risk of dementia for a person with obesity. But observational studies have limitations. They can suggest a hypothesis. Not prove causality. So the news of evidence from a Mendelian randomization study that obesity can cause vascular dementia is important. Methods and Findings This […]

All the research on obesity is not simply about tinkering with GLP-1s or developing the next blockbuster to surpass semaglutide and tirzepatide. This week, for instance, Science published research that opens a window to understanding how obesity activates inflammation. That inflammation leads to many of the complications that make obesity a complex, chronic disease. A […]

On the opening day of ObesityWeek yesterday, we got quite a treat in a passionate debate of the Lancet Commission report on clinical obesity. Four of our favorite people – Sue Yanovski, Bob Kushner, Fatima Cody Stanford, and Donna Ryan – participated and made it memorable. We walked away with a clear understanding that many […]

In the International Journal of Obesity, obesity medicine physician and researcher Caroline Apovian offers a compelling case to favor a prediabetes indication for GLP-1s. She writes: “The approval of a GLP-1 for prediabetes will change the landscape for prevention of T2DM and its complications due to early detection. Currently, most individuals at risk of T2DM […]

The magical Mirror of Erised can drive people mad by showing them their deepest desires. Judging by the flood of papers in recent days, it seems that one such desire is to find consensus for a clinical definition of obesity. In the past week alone, three such publications have crossed our screens. In the past […]

The evidence keeps building. Broadly, it is telling us that treating obesity is about much more than simply losing weight. It is about gaining health by managing the chronic disease of obesity and controlling it over time. Specifically this week, we have another piece of evidence to suggest that obesity treatment prevents cancer. In JAMA […]

This is stunningly positive news. While many of us are debating the nuances and evidence for lifestyle therapy in obesity, a clever group of cancer researchers have gone out and proven its value for extending life in people with colon cancer. A well-controlled clinical trial of personal coaching for exercise showed that it reduced cancer […]

As we are on the way to the European Congress on Obesity in  Málaga, Spain, one thing stands out. The science presented at this conference will make it plain that obesity is about much more than just excess weight and weight loss.We are looking forward to an array of presentations that deal with the effects […]

Late yesterday, the New England Journal of Medicine published interim results from a study that points to another breakthrough for semaglutide – this time for a MASH indication. The analysis includes 800 patients with MASH with an average BMI of 34.5. Only 22 patients in this trial had a BMI that indicated leanness. Nearly two […]